Clinically relevant disease is most prevalent in the elderly population, but early signs of AMD can also be found in individuals under 50 years of age 2. Our findings show that the choroidal vascular system in eyes with AMD is much more susceptible to damage in the presence than in the absence of systemic vascular disease.Īge-related macular degeneration (AMD) is a progressive disease leading to a severe decrease in visual acuity 1. No such associations were observed in the control group. ATC, AVC and average volume (AV) were lower in AMD patients with hypertension and ischaemic heart disease (IHD). A multivariate analysis adjusted for age, sex, and smoking status revealed that wet AMD was an independent factor associated with higher average thickness of the central ring area (ATC) and average volume of the central ring area (AVC) and lower choroidal vascularity index (CVI) compared to controls (β = + 0.18, p = 0.0007, β = + 0.18, p = 0.0008, respectively) and to dry AMD (β = + 0.17, p = 0.00003 for both ATC and AVC and β = − 0.30 p < 0.0001 for CVI). All participants underwent a complete ophthalmologic examination and assessment of choroidal thickness and volume. We enrolled 354 AMD patients (175 dry, 179 wet AMD) and 121 healthy controls. We aimed to assess changes in the choroidal volume and thickness in the macular region in AMD eyes and to investigate whether coexisting vascular risk factors alter choroidal status. Disturbances in choroidal microcirculation may lead to the onset and progression of age-related macular degeneration (AMD).
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